On January 1, 1995, Nintendo released several Game Boy models with colored cases, advertising them in the "Play It Loud!" campaign (Japanese name: Game Boy Bros. /ゲームボーイブロス/ゲームボーイブラザース). Specifications for this unit remain exactly the same as the original Game Boy, including the monochromatic screen. This new line of colored Game Boys would set a precedent for later Nintendo handhelds; the Game Boy Pocket, the Game Boy Color, Game Boy Advance (including the SP and Micro), all feature different colored units. Play It Loud! units were manufactured in red, green, black, yellow, white, blue, and clear (transparent) cases. The blue edition, for reasons unknown, was never depicted in any commercials or magazine advertisements in the United States, and is much harder to find than the other six. A very rare, limited edition Manchester United Game Boy is red, with the logos of the team emblazoned on it. It was released simultaneously with the Play it Loud! handhelds in the United Kingdom. The Play It Loud's screens also have a darker border than the normal Game Boy (with the exception of the black Play it Loud!).
- The Play it Loud! Game Boy is exactly the same as the original Nintendo Game Boy, but the Play it Loud! Game Boy has different colored shells, different colored buttons, and different colored screen lens.(Ex. A Radiant Red, Vibrant Yellow, Gorgeous Green, and etc. Play it Loud! Game Boys have all the buttons in black and the screen lens is black.
- The Traditional White Play it Loud! Game Boy is very similar to the original Nintendo Game Boy, but the traditional white Play it Loud! Game Boy has the all the buttons in black, and the screen lens is black.